Serum cytokines and bone turn over markers: a cross sectional study in Karachi Pakistan
Keywords:
Vitamin D (VD), Vitamin D Binding Protein (VDBP), Tumor Necrosis Factor Alpha (TNF α), Interleuking-6 (IL-6), Osteocalcin and C-Terminal Telopeptide (CTX), Body mass index (BMAbstract
Objectives: To predict marker of osteoporosis and osteopenia in female population of Karachi, Pakistan.
Methodology: This cross-sectional study was performed from June 2017 to August 2019 in “Department of Biological and Biomedical Sciences, Aga Khan University Hospital” on 245 female subjects, age range 25 to 70 years; categorized into normal (T-score ≥ -1), osteopenic (T-score -1.1 to -2.4) and osteoporotic (T-score <-2.5) by dual-energy X-ray absorptiometry (DEXA) scan.Vitamin D (VD), Vitamin D Binding Protein (VDBP), Tumor Necrosis Factor Alpha (TNF α), Interleuking-6 (IL-6), Osteocalcin and C-Terminal Telopeptide (CTX) were analyzed by Enzyme Linked Immunosorbent Assay. Analysis of Variance (ANOVA) and spearman’s rank correlation test was performed to compare the difference and association among groups. Regression analysis used to predict factors responsible for osteopenia /osteoporosis.
Results: There were 105 (42.9%), 84 (34.3%) and 56 (22.8%) females in normal, osteopenia and osteoporosis groups respectively. The mean serum values of VD, TNF, IL-6 and CTX were found to be significantly diverse in all three groups (p<0.005). VD had a significant negative correlation with BMI, TNF, IL-6, osteocalcin and CTX. A robust positive correlation was observed between VD and VDBP (r= 0.596, p<0.001).
It was noted that with every one unit increase in BMI the prevalence of osteopenia was decreased by 72% (p<0.05) and prevalence of osteoporosis was significantly decreased by 66.2% (p<0.05) and with every one unit increase in VDBP levels the prevalence of osteoporosis was significantly decreased by 56.4% (p<0.05).
Conclusion: BMI and VDBP levels were found to be predictive factors for osteopenia and osteoporosis. These findings emphasize on the importance of monitoring Vitamin D levels, BMI, and VDBP to assess bone health and predict the risk of osteoporosis and osteopenia in the female population of Karachi, Pakistan.
How to cite this: Azhar A, Hakeem S, Afzal K, Riffat S, Ashraf M, Rehman R. Serum cytokines & bone turn over markers: A cross sectional study in Karachi Pakistan. JPES. 2024;1(1):3-8.
